The role of TIR8 and PTX3 in sepsis induced immunosuppression
Instituto Clinico Humanitas, Milan, Italy
After I finished my bachelor’s degree in the medical laboratory, I got my master’s degree in Immunology at Iran University of Medical Sciences, Tehran, Iran. My master’s thesis was focused on the effect of probiotic feeding on T cell populations in blood and lymphoid organs. At the same time, I expanded my master thesis in a research institute called Pediatric Infectious Diseases Research Center, working on Toll-Like Receptors expression. In 2017, I moved to Italy and started my Ph.D. in ESA-ITN project under the Marie Sklodowska-Curie scholarship at Instituto Clinico Humanitas (ICH) under the supervision of Prof. Alberto Mantovani and Prof. Cecilia Garlanda. At ICH, as a member of ESA-ITN project, taking advantage of gene-targeted mice, we are evaluating the involvement of TIR8 and PTX3 in the pathogenesis of sepsis. Murine sepsis associated with infections caused by diverse microbes will be used to compare the susceptibility and the inflammatory response of immunocompetent, PTX3- and TIR8-deficient mice, and to address the mechanisms underlying defective resistance to infections and exacerbated inflammation or immunosuppression.