ESR 5 Eleni Karakike

Project

Linking the microRNAome and DNA methylation analysis with distinct septic transcriptional responses that characterize immunosuppression.

Partner

University of Athens

Nationality

Belgian

Short CV

In 2007 I got my master degree in Medicine at Medical School of the National and Kapodistrian University of Athens. Afterwards I have moved to Belgium to pursue my medical specialty training in Internal Medicine at Université Libre de Bruxelles (ULB). In 2013 I did a special training in infectious diseases (ULB, Université Catholique de Louvain- UCL and Université de Liège-ULG) and obtained the title of Specialist in Internal Medicine (2015) and Infectious Diseases (2016). I then started working as a consultant in Brugmann University Hospital, Department of Infectious Diseases. I also obtained a certificate of expertise in Antibiotic Management and Stewartship (organized by ULB, UCL and ULG, Belgium, 2017). Since 2017, I have had the opportunity to be enrolled in one of the European projects under the Marie Sklodowska-Curie scholarship called European Sepsis Academy-Innovative Training Network. I have moved to Athens, Greece, as an early stage researcher in the University of Athens and am currently working to obtain my PhD under the supervision of Pr. Giamarellos-Bourboulis.

The subject of my research is to design and perform an international, multicenter, randomized, double blind, placebo-controlled clinical trial on clarithromycin in septic patients with multiple organ dysfunction syndrome and hospital-acquired infections (INtravenous CLArithromycin in Sepsis and multiple organ dysfunction Syndrome, INCLASS study). Transcriptomic and genomic profiling is prospectively performed overtime in well-characterized patients and linked to clinical outcomes in order to identify biomarkers for risk stratification and response to treatment, while testing the effect of clarithromycin in immunoparalysis reversal.

Contact

elkarakike@med.uoa.gr