Publications

Publications

2018

  • Wiersinga WJ, Virk HS, Torres AG, Currie BJ, Peacock SJ, Dance DAB, Limmathurotsakul D. Nat Rev Dis Primers. 2018 Feb 1;4:17107.
  • The Emerging Role of the Microbiome in the ICU. Nora Suzanne Wolff, Floor Hugenholtz and Willem Joost Wiersinga. Critical Care. 2018;22:78. doi:10.1186/s13054-018-1999-8. doi:  10.1186/s13054-018-1999-8
  • Ciarlo E, Heinonen T, Théroude C, Herderschee J, Mombelli M, Lugrin J, Pfefferlé M, Tyrrell B, Lensch S, Acha-Orbea H, Le Roy D, Auwerx J, Roger T. Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection. Front Immunol. 2017 Aug 28;8:1037. PMID: 28894448.
  • Tytti Heinonen, Eleonora Ciarlo, Charlotte Théroude, Aimilia Pelekanou, Jacobus Herderschee, Didier Le Roy and Thierry Roger; Sirtuin 5 deficiency does not compromise innate immune responses to bacterial infections; Front. Immunol. | doi: 10.3389/fimmu.2018.02675
  • Wolff N.S., Hugenholtz F., Wiersinga W.J. (2018) In: Vincent JL. (eds) Annual Update in Intensive Care and Emergency Medicine 2018. Springer, Cham.[dual publication]
  • Chloé Albert-Vega, Dina M. Tawfik, Sophie Trouillet-Assant, Laurence Vachot, François Mallet and Julien Textoris. Immune Functional Assays, From Custom to Standardized Tests for Precision Medicine. Immunol., 16 October 2018. doi.org/10.3389/fimmu.2018.02367
  • Alban, A., Chick, S. E., and Forster, M. Extending a Bayesian decision-theoretic approach to value-based sequential clinical trial design. (In Proceedings of the 2018 Winter Simulation Conference, 2459-2470, Piscataway, NJ. IEEE, Inc.)
  • Strouvalis I, Routsi C, Adamopoulou M, Raftogiannis M, Renieris G, Orfanos SE, Kotanidou A, Sabracos L, Giamarellos-Bourboulis EJ. 2018. Early increase of VEGF‐A is associated with resolution of ventilator‐associated pneumonia: Clinical and experimental evidence. Respirology 2018, 23 (10): 942-949.

 

2019

  • Eleni Karakike, Maria-Evangelia Adami, Malvina Lada, Theologia Gkavogianni, Ioannis M. Koutelidakis, Michael Bauer, Evangelos J. Giamarellos-Bourboulis, Iraklis Tsangaris. Late Peaks of HMGB1 and Sepsis Outcome. Shock. 2018 Sep 19. doi: 10.1097/SHK.0000000000001265.
  • Karakike, J. Giamarellos-Bourboulis. Macrophage Activation-Like Syndrome: A Distinct Entity Leading to Early Death in Sepsis. Front Immunol. 2019 Jan 31;10:55. doi: 10.3389/fimmu.2019.00055. eCollection 2019
  • Schrijver IT, Théroude C, Roger T. Myeloid-Derived Suppressor Cells in Sepsis. Front Immunol. 2019 Feb 27;10:327. doi: 10.3389/fimmu.2019.00327. eCollection 2019.
  • Poulakou G, Renieris G, Sabrakos L, Zarkotou O, Themeli-Digalaki K, Perivolioti E, Kraniotaki E, Giamarellos-Bourboulis EJ, Zavras N. Daptomycin as adjunctive treatment for experimental infection by Acinetobacter baumanii with resistance to colistin. Int J Antimicrob Agents. 2019, 53 (2): 190-194.
  • Chloé Albert Vega, Marine Mommert, Mathilde Boccard, Thomas Rimmelé, Fabienne Venet, Alexandre Pachot, Veronique Leray, Guillaume Monneret, Benjamin Delwarde, Karen Brengel-Pesce, François Mallet and Sophie Trouillet-Assant. Source of Circulating Pentraxin 3 in Septic Shock Patients. Front. Immunol., 04 January 2019. [click to read paper]

Posters

2017

  • Regulation of the expression of IL-1R8, a regulatory member of the Interleukin-1 receptor family. Supino D, Molgora M, Ponzetta A, Barbagallo M, Magrini E, Berthenet K, Gianni F, Asgari F,Perucchini Ch, Jaillon S, Mantovani A and Garlanda C. (May 2017, Bari, Italy, SIICA congress)
  • The long pentraxin PTX3 has a non-redundant role in the control of Streptococcus pneumoniaeinvasive infections. Porte R, Davoudian S, Asgari F, Parente R, Sironi M, Pasqualini F, Barbagallo M, Silva-Gomes R, Van der Poll T, Garlanda C, Bottazzi B and  Mantovani A. (Sep 2017, ISF 11th annual symposium, Paris, France)
  • Schrijver I, Roger T, Calandra T. Dynamic profiling of MDSCs in sepsis. 7thJoint EPFL-UNIL PhD Retreat. (March 2017, Les Diablerets, Switzerland)
  • Théroude C, Calandra T, Roger T. Innate lymphoid cells in sepsis. 7thJoint EPFL-UNIL PhD Retreat.(March 2017, Les Diablerets, Switzerland)
  • BACH1 (BTB and CNC homology 1), the oncogenic regulator enhances migration of HT-29 colon cancer cells. Sadaf Davoudian, Neda Shajari, Shima Salehi, Behzad Mansoori, Ali Mohammadi, Behzad Baradaran. (May 2017, Bari, Italy, SIICA congress)
  • The long pentraxin PTX3 has a non-redundant role in the control of Streptococcus pneumoniae invasive infections. Porte Rémi, Davoudian Sadaf, Asgari Fatemeh, Parente Raffaella, Sironi Marina,2 Pasqualini Fabio, Barbagallo Maria Luisa, Silva-Gomes Rita, Van der Poll Tom, Garlanda Cecilia, Bottazzi Barbara and  Mantovani Alberto. (Sep 2017, ISF 11thannual symposium, Paris, France)
  • PTX3 and factor H functionally cooperate in promoting phagocytosis of Aspergillus fumigatus. Parente R, Petroni F., Porte R. , Sadaf Davoudian, Sironi M., Valentino S.1, Bottazzi B., Mantovani A., Inforzato A. (May 2017, Bari, Italy, SIICA congress)

2018

  • Heinonen T, Ciarlo E, Théroude C, Le Roy D, Auwerx J, Roger T. Sirtuin 5 deficiency has no major impact on innate immune responses to bacterial infections (Research Day of the Department of Medicine, CHUV, Lausanne, February 28 2018.)
  • Heinonen T, Ciarlo E, Théroude C, Le Roy D, Auwerx J, Roger T. Sirtuin 5 deficiency does not compromise innate immune responses to bacterial infections (5th European Congress of Immunology (ECI) 2018, Amsterdam, Netherlands, September 2-5 2018)
  • Ciarlo E, Heinonen T, Théroude C, Pelekanou A, Herderschee J, Le Roy D and Roger T. Sirtuin 5 deficiency does not compromise innate immune responses to bacterial infections.( Joint Annual Meeting 2018 of the Swiss Societies for Infectious Diseases (SSI), Hospital Hygiene (SSHH), Tropical Medicine and Parasitology (SSTMP) and the Swiss Society of Tropical and Travel Medicine (SSTTM), Interlaken, September 13-14 2018)
  • Nora Suzanne Wolff et al., Vendor effects on murine gut microbiota and its influence on lipopolysaccharide induced lung inflammation and Gram-negative pneumonia. (New Frontiers in Innate Immunity & Inflammation, Sept. 2018, Cluj, Romania).
  • Dina M. Tawfik et al., Immune profiling of host response biomarkers through transcriptomic analysis using FilmArray system. ISICEM conference, Brussels, Belgium. March2018
  • Eleni Karakike, Iraklis Tsangaris, Athina Savva, ChrisFna Routsi, Konstantinos Leventogiannis, Maria Tsilika, Vassiliki Apollonatou, Ioannis Tomos, Jean-Louis Vincent, Evangelos J Giamarellos-Bourboulis. Can early changes in SOFA score predict early outcome? An analysis of two cohorts. 38th ISICEM conference, Brussels, Belgium. March 2018

2019

  • Heinonen T, Ciarlo E, Rigoni E, Regina J, Théroude C, Le Roy D, Roger T. The sirtuins SIRT2 and SIRT3 act in concert to modulate innate immune responses.(Research Day of the Department of Medicine, CHUV, Lausanne, February 21 2019)
  • Schrijver IT, Théroude C, Calandra T, Roger T. Diagnostic Profiling of MDSCs in Sepsis. (9th joint EPFL-UNIL PhD Retreat, Les Diablerets, Switzerland, March 01-03 2019)
  • Schrijver IT, Herderschee J, Theroude C, Fenwick C, Baumgartner P, Harari A, Leijte G, Kox M, Pantaleo G, Pickkers P, Calandra T, Roger T. Myeloid-derived suppressor cells (MDSCs) in healthy subjects infused with endotoxin. (Day 2019, Lausanne, April 10 2019)
  • Théroude C, Porte R, Bottazzi B, Schrijver IT, Calandra T, Garlanda C, Roger T. Modulation of innate lymphoid cells (ILCs) during sepsis induced by pneumococcal infection. (Day 2019, Lausanne, April 10 2019)
  • Schrijver IT, Herderschee J, Theroude C, Fenwick C, Baumgartner P, Harari A, Leijte G, Kox M, Pantaleo G, Pickkers P, Calandra T, Roger T. Myeloid-derived suppressor cells (MDSCs) in healthy subjects infused with endotoxin. (Joint Annual Meeting 2018 of the Swiss Societies for Intensive Medicine (SSMI), Infectious Diseases (SSI), Hospital Hygiene (SSHH), Tropical Medicine and Parasitology (SSTMP) and the Swiss Society of Tropical and Travel Medicine (SSTTM), EPFL-Lausanne, September 18-20 2019)
  • Théroude C, Porte R, Bottazzi B, Schrijver IT, Calandra T, Garlanda C, Roger T. Innate lymphoid cells (ILCs) during S.pneumoniae pneumonia. (Joint Annual Meeting 2018 of the SSMI, SSI, SSHH, SSTMP and SSTTM, EPFL-Lausanne, September 18-20 2019)
  • Karakike, M.Roumpoutsou, N.Karampela, E. Massa, E.Antypa, K.Psaroulis, P.Chaloulis, E.Pappa, V.Kolonia, E. J. Giamarellos-Bourboulis, I. Tsangaris. A double- blind, randomized, placebo-controlled clinical study of the efficacy of intravenous clarithromycin as adjunctive treatment in patients with sepsis and respiratory and multiple organ dysfunction syndrome: the INCLASS study. 39th ISICEM conference, Brussels, Belgium, March 2019
  • Karakike, A. Alban, E.J. Giamarellos-Bourboulis, S.E. Chick. Exploring alternative trial designs for pragmatic clinical studies: A Bayesian decision-theoretic model applied on a real ongoing one-stage trial. 39th ISICEM conference, Brussels, Belgium, March 2019
  • Renieris G., Karageorgos A., Bauer M., Sabrakos L, Papapetropoulos A, Giamarellos-Bourboulis EJ. Impact of host-derived hydrogen sulphide production on susceptibility to Pseudomonas aeruginosa infection: evidence for altered quorum system gene expression. 29th ECCMID (April 2019, Amsterdam, Netherlands). [click to see poster]
  • Chloé Albert Vega*, Brengel-Pesce K, Lopez J, Desormeaux P, Pachot A, Rimmelé T, Venet F, Leray V, Monneret G, Delwarde B, Mallet F, Trouillet-Assant S. Deciphering heterogeneity in Septic Shock Patients using Immune Functional Assays: a proof of concept study. 29th ECCMID (April 2019, Amsterdam, Netherlands). [click to see poster]
  • Chloé Albert Vega: “Immune dysfunction-based stratification of septic shock patients: a proof-of-concept study”. XVIIIth congress of the European Shock Society and IXth Congress of the Int Federation of shock societies (October 2019, Crete)

Presentations

2017

  • Berke Gurkan:“Structure Function of IRAK-M” at the Masterclass Prof Douglas Golenbeck, AMC, The Netherlands
  • Nora Wolff:The difference of murine gut microbiota between different vendors, does it impact infection pathogenesis?” AMC Centre of Molecular Medicine department meeting, AMC, The Netherlands
  • Vera Peters: “Future Research Question in Sepsis” at the ESCMID 2017 postgraduate Sepsis Summer Course. (June 2017, Amsterdam, The Netherlands)
  • Chloe Albert: Presented her work at the Mérieux Université PhD day (May 2017, Lyon, France)
  • Dina Tawfik: Presented her work at the Mérieux Université PhD day (May 2017, Lyon, France)
  • Harjeet Virk: “Future Research Question in Sepsis” at the ESCMID 2017 postgraduate Sepsis Summer Course. (June 2017, Amsterdam, The Netherlands)

All ESRs presented their projects to the ESA-ITN satellite meetings taking place during Sepsis 2017 (13.09.17, Paris).

2018

  • Andres Alban: “Extending a Bayesian decision-theoretic approach to value-based sequential clinical trial design” at the 2018 Winter Simulation Conference (December 2018, Gothenburg, Sweden)
  • George Renieris: «Daptomycin as adjunctive treatment for experimental infection by Acinetobacter baumanii with resistance to colistin». 21ο Panhellenic Congress of Internal Medicine (October 2018, Athens, Greece).
  • Chloe Albert: «Definition of an immune functional assay to characterized the altered immune status observed in sepsis patients ». Immune Functional Assay course “IFA day” (March 2018, Biomérieux, France)
  • Chloe Albert: Presented her work at the Mérieux Université PhD day (May 2018, Lyon, France)
  • Dina Tawfik: Presented her work at the Mérieux Université PhD day (May 2018, Lyon, France)
  • Chloe Albert: «Definition of an immune functional assay to characterized the altered immune status observed in sepsis patients ». Center For Experimental And Molecular Medicine (CEMM)- Amsterdam University Medical Center (October 2018, Amsterdam, The Netherlands)
  • Dina Tawfik: «Immunoprofiling of ICU patients using FilmArray® Platform». Center For Experimental And Molecular Medicine (CEMM)- Amsterdam University Medical Center (June 2018, Amsterdam, The Netherlands)
  • Dina Tawfik: «Design of a fully integrated molecular tool to manage sepsis patients based on their immune status». Ecole Doctorale Interdisciplinaire Sciences –Sante (EDISS) PhD Day- Claude Bernard University Lyon-1 (October 2018, Lyon, France)

2019

  • Eleni Karakike: « Macrophage activation: A new mechanism of pathogenesis in sepsis » Annual National Training Program in Infectious Diseases 2018-2019 « Hot Topics in Infectious Diseases –Sepsis 2018» Hellenic Society of Infectious Diseases (February 2019, Athens, Greece)
  • Schrijver IT. Diagnostic profiling of MDSCs in sepsis. Congress of Hellenic sepsis study group, 08.06.2018, Marathon, Greece
  • Andres Alban: «Cost-Effective Clinical Trial Design: Application of a Bayesian Sequential Stopping Rule to the ProFHER Pragmatic Trial »  5th International Clinical Trials Methodology Conference (ICTMC 2019), Brighton. https://ictmc2019.com/
  • Chloe Albert: «Definition of an immune functional assay to characterized the altered immune status observed in sepsis patients ». Center For Experimental And Molecular Medicine (CEMM)- Amsterdam University Medical Center (June 2019, Amsterdam, The Netherlands)

Other publications acknowledging ESA-ITN:

Peer-reviewed articles:

  • Rello J, van Engelen TSR, Alp E, Calandra T, Cattoir V, Winfried V. Kern WV, Netea MG, Nseir S, Opal SM, van de Veerdonk FL, Wilcox MH, Wiersinga WJ. Towards precision medicine in sepsis: a position paper of the European Society of Clinical Microbiology and Infectious Diseases. Clinical Microbiology and Infection, 2018 In press
  • New: Research Topic on “The Immunology of Sepsis – Understanding Host Susceptibility, Pathogenesis of Disease, and Avenues for Future Treatment”, edited by Roger T. Frontiers in Immunology. This special theme issue will be dedicated to the European Sepsis Academy (in preparation)
  • Chick SE, M Forster, P Pertile, 2017, A Bayesian Decision-Theoretic Model of Sequential Experimentation with Delayed Responses, Journal Royal Statistical Society Series B, 79(5): 1439—1462, http://onlinelibrary.wiley.com/doi/10.1111/rssb.12225/abstract
  • van der Sluijs AF, ER van Slobbe-Bijlsma, SE Chick, MB Vroom, DA Dongelmans, APJ Vlaar, 2017, The impact of changes in intensive care organization on patient outcome and cost effectiveness – A narrative review, https://dx.doi.org/10.1186/s40560-016-0207-7
  • SE Chick, N Gans, O Yapar, in preparation, Bayesian Sequential Learning for Clinical Trials of Multiple Correlated Technologies, in preparation.

Books and bookchapters:

  • Giesen L, Luuk Giesen MD. What is sepsis? In: Wiersinga WJ, Seymour CW (ed). Handbook of Sepsis. Springer Nature, 2018 In press
  • Engelen TSR, Wiersinga WJ, van der Poll T. The pathogenesis of sepsis. In: Wiersinga WJ, Seymour CW (ed). Handbook of Sepsis. Springer Nature, 2018 In press
  • Wiersinga WJ, Seymour CW (ed). Handbook of Sepsis. Springer Nature, 200 p, 2018 In press